Journal of Organic Chemistry p. 11529 - 11537 (2015)
Update date:2022-08-05
Topics:
Kerdphon, Sutthichat
Quan, Xu
Parihar, Vijay Singh
Andersson, Pher G.
N-Heterocyclic carbene-phosphine iridium complexes (NHC-Ir) were developed/found to be a highly reactive catalyst for N-monoalkylation of amides with alcohols via hydrogen transfer. The reaction produced the desired product in high isolated yields using a wide range of substrates with low catalyst loading and short reaction times.
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