M. Takahashi et al. / Tetrahedron Letters 44 (2003) 9201–9203
9203
for Scientific Research from The Ministry of Education,
Science, Sports, and Culture. The financial supports from
Chugai Pharmaceutical Company and Takahashi Indus-
trial and Economic Research Foundation are also
acknowledged. The authors also deeply grateful to Pro-
fessor M. Hayashi (Kobe University) for valuable discus-
sions.
Figure 5. Treatment of allylic alcohol 5 with rhodium catalyst
and methyl acrylate.
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Figure 6. Isomerization of a cycloalkenol into a saturated
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1
2
3
4
5
6
7
RuCl2(PPh3)3
RhCl(CO)(PPh3)2
NiCl2
Ru3(CO)12
RhCl3
88%
<5
<5
19
6
<5
28
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Pd2Cl4(PPh3)2
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Figure 7. Isomerization of alkenol 10 into a saturated ketone
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The transition metal catalyzed intermolecular hydride
shift from alkanol to enone was promoted effectively by
microwave irradiation. In the same way, ruthenium-cat-
alyzed intramolecular hydride shift was also accelerated
by microwave irradiation. The procedures are simple and
will give a way for microwave chemistry concerning
organometallic chemistry.
Acknowledgements
This work was supported financially by a Grant-in-Aid