Journal of Medicinal Chemistry p. 717 - 722 (1980)
Update date:2022-07-30
Topics:
Dillard
Yen
Stark
Pavey
A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood-pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.
View MoreWuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Chongqing Werlchem Fine Chemical Co. Ltd
Contact:+86-23-67521957
Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Doi:10.1021/acsmedchemlett.8b00062
(2018)Doi:10.1016/j.tet.2017.04.013
(2017)Doi:10.1021/ja00820a024
(1974)Doi:10.1016/j.bmcl.2003.11.070
(2004)Doi:10.1016/j.tetasy.2003.10.026
(2004)Doi:10.1016/j.molstruc.2003.12.002
(2004)