Canadian Journal of Chemistry p. 690 - 696 (2019)
Update date:2022-08-05
Topics:
Vinaya, Kambappa
Chandrashekara, Ganganahalli K.
Shivaramu, Prasanna D.
1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.
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Doi:10.1039/b316262a
(2004)Doi:10.1021/ja01189a079
(1948)Doi:10.1007/BF00925433
()Doi:10.1021/jo0499221
(2004)Doi:10.1016/j.jorganchem.2004.01.029
(2004)Doi:10.1016/S0022-328X(00)85541-2
(1981)