CONVENIENT SYNTHESIS OF 14,15-EET
5
0.40 mmol) in CH2Cl2 (2 mL) under argon at room temperature. The mixture was
stirred for 30 min, when MeOH (170 mL, 4.1 mmol) was added and the reaction mix-
ture was stirred for another 4 h at room temperature. The solvents were removed and
the residue was purified by flash column chromatography, eluting with hexanes–
1
EtOAc (10:1) to give 5 (70 mg, 0.21 mmol, 52%) as a colorless oil. The H NMR
characterization data are identical to the literature values.[16] 1H NMR (400 MHz,
CDCl3) d 5.55–5.41 (m, 2 H), 5.40–5.31 (m, 4 H), 3.67 (s, 3 H), 2.97–2.80 (m,
2 H), 2.86–2.76 (m, 4 H), 2.45–2.36 (m, 1 H), 2.32 (t, J ¼ 7.5 Hz, 2 H), 2.27–2.17
(m, 1 H), 2.10 (q, J ¼ 7.0 Hz, 2 H), 1.70 (quintet, J ¼ 7.5 Hz, 2 H), 1.57–1.41 (m, 4
H), 1.37–1.27 (m, 4 H), 0.90 (t, J ¼ 7.0 Hz, 3 H).
ACKNOWLEDGMENTS
We are grateful for Dr. Sanjiv Kaul for discussions and the Knight
Cardiovascular Institute.
FUNDING
We are thankful for the philanthropic support from Philip and Penny Knight.
SUPPLEMENTAL MATERIAL
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