Journal of Medicinal Chemistry p. 855 - 862 (1979)
Update date:2022-07-29
Topics:
Klayman
Bartosevich
Griffin
Mason
Scovill
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.
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Doi:10.1021/acs.joc.0c02764
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