Research on Chemical Intermediates p. 7963 - 7975 (2016)
Update date:2022-08-04
Topics:
Ghasemi, Mohammad Hadi
Kowsari, Elaheh
Abstract: An efficient synthesis of cyclopropanecarboxylic acids using copper chromite spinel nanoparticles and basic ionic liquid is described. In this study, a relatively simple method starting with trans-cinnamic acid for the synthesis of (±)-trans-2-phenylcyclopropanecarboxylic acid, a key intermediate in the synthesis of tranylcypromine sulfate as an active pharmaceutical ingredient, was employed. Using a combination of basic ionic liquid [Bmim]OH and copper chromite spinel nanoparticles as a catalytic system, the best results were obtained in THF as a polar solvent. This method is a useful alternative to other approaches described in the literature. The use of commercially available chemicals, decreased environmental hazards, with no need for the separation of stereoisomers, and consequently a reduced number of overall steps, are the advantages of this approach that make it an appropriate choice at an increased scale. Graphical Abstract: [Figure not available: see fulltext.]
View MoreBeijing Cooperate Pharmaceutical Co.,Ltd
Contact:86-01060279497
Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Jiangsu Glory Chemical Co., Ltd.
Contact:+86-571-87896791
Address:Yanhua Chemical Park, Hongze, Huai'an, Jiangsu, China
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED
Contact:+86-0532-82683616
Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
xi'an taima biological engineering co., ltd.
Contact:+8615619038117
Address:6 No,keji road xi'an city of china
Doi:10.1021/jo01332a007
(1979)Doi:10.1016/j.tetlet.2016.09.087
(2016)Doi:10.1039/c8ce00426a
(2018)Doi:10.1080/15421400500374575
(2006)Doi:10.1016/j.tetlet.2004.03.099
(2004)Doi:10.1021/ja01862a060
(1940)