Organic Letters
Letter
Fiebig, H.-H.; Lin, W.-H.; Hertweck, C. Org. Biomol. Chem. 2011, 9,
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simple substrates in a straightforward and efficient manner.
Bearing picolinamide as a directing group, the alkenyl anilines
(1a−o) cyclized to afford spiro-dihydroquinolines (2a−o) in
moderate to excellent yields via direct oxidative arylation, while
the alkenyl benzylamines (3a−d) furnished the octahydrophe-
nanthrene derivatives (5a−d) in moderate yields via sequential
oxidative arylation and double acetoxylation. Studies to establish
asymmetric oxidative arylation are currently ongoing in our
laboratory.
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ASSOCIATED CONTENT
* Supporting Information
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S
The Supporting Information is available free of charge on the
Experimental procedures, characterization of the products,
X-ray analysis, and NMR spectra (PDF)
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AUTHOR INFORMATION
Corresponding Authors
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ORCID
Author Contributions
†Z.-L.Z. and S.K. contributed equally.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
́ ́
Zhu, J. Angew. Chem., Int. Ed. 2016, 55, 9714−9718. (m) Perez-Gomez,
■
́
M.; García-Lopez, J.-A. Angew. Chem., Int. Ed. 2016, 55, 14389−14393.
(n) Liu, X.; Gu, Z. Org. Chem. Front. 2015, 2, 778−782.
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2003, 125, 9578−9579. (c) Baran, P. S.; Corey, E. J. J. Am. Chem. Soc.
2002, 124, 7904−7905.
We are grateful for financial support from the National Natural
Science Foundation of China (21372267, 21402150, 21572027,
21602023), a Postdoctoral Research Grant (2016M602658),
and Chongqing Research and Frontier Technology
(cstc2016jcyjA0403). We thank Dr. Yong-Liang Shao (Lanzhou
University) and Xiangnan Gong (Chongqing University) for the
X-ray crystallographic analysis.
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