Journal of Organic Chemistry p. 13841 - 13857 (2019)
Update date:2022-08-15
Topics:
Xia, Aiyou
Xie, Xin
Hu, Xiaoping
Xu, Wei
Liu, Yuanhong
The general dehalogenation of alkyl halides with zinc using D2O or H2O as a deuterium or hydrogen donor has been developed. The method provides an efficient and economic protocol for deuterium-labeled derivatives with a wide substrate scope under mild reaction conditions. Mechanistic studies indicated that a radical process is involved for the formation of organozinc intermediates. The facile hydrolysis of the organozinc intermediates provides the driving force for this transformation.
View Morechengdu firsterchem Pharmaceutical Co., Ltd.
Contact:028-66825849
Address:chengdu
GUANGZHOUGRENSPSPORTS FACILITIES CO LTD
Contact:
Address:
Guangzhou Chemical Reagent Factory
Contact:+86-20-8435 9820 or 8435 7345
Address:Southern Guangzhou, Guangdong, China
Xi'an HO-SHINE Bio-Technology Co., Ltd
Contact:+86 (29) 8248-5435/18292020086
Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
Suzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Doi:10.1246/cl.1987.841
(1987)Doi:10.1016/S0020-1693(00)90958-7
(1980)Doi:10.1016/S0040-4039(00)72730-4
(1989)Doi:10.1007/BF01118746
()Doi:10.1016/S0008-6215(00)83672-1
(1980)Doi:10.1002/hlca.19570400123
(1957)