Journal of labelled compounds and radiopharmaceuticals p. 1151 - 1160 (2003)
Update date:2022-07-30
Topics:
Yu
Kim
Kim
Park
Yang
Herdering
Knoechel
N-4-(4-chlorophenyl)butyl-N,N-diethyl-7-[ 18F]fluoroheptylammonium ([18F]-fluoroclofilium) has been prepared as a potential cardiac imaging agent. For the synthesis of this radiolabelled ammonium salt, its tosyloxylated analogue was prepared as a precursor, and the non-radioactive fluorine analogue was synthesized as a reference compound. Radiofluorination was achieved by the treatment of N-4-(4-chlorophenyl)butyl-N,N-diethyl-7-(p-toluenesulfonyloxy)-heptylammonium p-toluenesulfonate with 18F- in the presence of Kryptofix-2.2.2 in acetonitrile. Copyright
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