Synthetic Communications p. 751 - 759 (2015)
Update date:2022-08-04
Topics:
Rahmani-Nezhad, Samira
Khosravani, Leila
Saeedi, Mina
Divsalar, Kouros
Firoozpour, Loghman
Pourshojaei, Yaghoub
Sarrafi, Yaghoub
Nadri, Hamid
Moradi, Alireza
Mahdavi, Mohammad
Shafiee, Abbas
Foroumadi, Alireza
A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities. GRAPHICAL ABSTRACT.
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