Molecules 2021, 26, 4331
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4.1.5. Synthesis of Bis-(tert-leucinato)palladium(II) (5)
Following the standard procedure, 0.0325 g palladium(II) acetate (1.45
×
10−4 mol)
and tert-leucine (3.18
×
10−4 mol, 2.2 equivalents) were combined. The yield of product was
50.6 mg (0.1378 mmol, 95% yield). Pd(C6H12NO2)2 was identified based on the following
data: 1H NMR (400 MHz, Deuterium Oxide)
δ 3.16 (s, 1H), 0.94 (s, 9H). HRMS/ESI+
(m/z): [M + H]+ calcd for Pd(C6H12NO2)2, 367.0844; found, 367.0877. Anal. Calcd. for
Pd(C6H12NO2)2: C, 39.30%; H, 6.60%; N, 7.64%. Found: C, 39.47%; H, 6.59%; N, 7.70%.
4.1.6. Synthesis of Bis-(leucinato)palladium(II) (6)
Following the standard procedure, 0.0517 g palladium(II) acetate (2.30
×
10−4 mol)
and 0.0665 g leucine (5.07
×
10−4 mol, 2.2 equivalents) were combined. The yield of
product was 82.1 product (0.2239 mmol, 97% yield). Pd(C6H12NO2)2 was identified based
1
on the following data: H NMR (400 MHz, Deuterium Oxide)
δ
3.63–3.53 (m, 1H), 1.65–1.55
(m, 1H), 1.60–1.44 (m, 2H), 0.90–0.72 (m, 6H). 13C NMR (101 MHz, D2O)
δ 175.70, 53.57,
39.94, 24.30, 22.16, 21.02. HRMS/ESI+ (m/z): [M + Na]+ calcd for Pd(C6H12NO2)2, 389.0663;
found, 389.0692.
4.1.7. Synthesis of Bis-(tryptophanato)palladium(II) (7)
Following the standard procedure, 0.0799 g palladium(II) acetate (3.56
×
10−4 mol)
and 0.1599 g tryptophan (7.83
×
10−4 mol, 2.2 equivalents) were combined The yield of
product was 178.2 mg (0.3475 mmol, 98% yield). Pd(C11H11N2O2)2 was identified based
1
on the following data: H NMR (400 MHz, DMSO-d6)
δ
7.59–6.84 (m, 5H), 4.69–3.73 (m,
2H), 3.47–3.33 (m, 1H). HRMS/ESI+ (m/z): [M + H]+ calcd for Pd(C11H11N2O2)2, 513.0749;
found, 513.0700. Anal. Calcd. for Pd(C11H11N2O2)2·H2O: C, 49.77%; H, 4.56%; N, 10.55%.
Found: C, 49.00%; H, 4.51%; N, 10.41%.
4.1.8. Synthesis of Bis-(phenylalaninato)palladium(II) (8)
Following the standard procedure, 0.1067 g palladium(II) acetate (4.75
×
10−4 mol)
and 0.1727 g phenylalanine (1.05
×
10−3 mol, 2.2 equivalents) were combined. The product
yield was 190.1 mg (0.4373 mmol, 92% yield). Pd(C9H10NO2)2 was identified based on
1
the following data: H NMR (400 MHz, Deuterium Oxide)
δ
7.34–7.14 (m, 5H), 3.89–3.82
(m, 1H), 3.15 (dd, J = 14.5, 5.2 Hz, 1H), 2.98 (dd, J = 14.5, 8.0 Hz, 1H). HRMS/ESI+ (m/z):
[M + H]+ calcd for Pd(C9H10NO2)2, 435.0531; found, 435.0538.
4.1.9. Synthesis of Bis-(tyrosinato)palladium(II) (9)
Following the standard procedure, 0.0511 g palladium(II) acetate (2.28
×
10−4 mol)
and 0.0907 g tyrosine (5.01
×
10−4 mol, 2.2 equivalents) were combined. The product
yield was 92.1 mg (0.1973 mmol, 87% yield). Pd(C9H10NO3)2 was identified based on the
1
following data: H NMR (400 MHz, Deuterium Oxide)
δ
7.11–7.04 (m, 2H), 6.83–6.73 (m,
2H), 3.82 (dd, J = 7.8, 5.2 Hz, 1H), 3.09 (dd, J = 14.7, 5.2 Hz, 1H), 2.94 (dd, J = 14.7, 7.8 Hz,
1H). HRMS/ESI+ (m/z): [M + H]+ calcd for Pd(C9H10NO3)2, 467.0429; found, 467.0448.
4.1.10. Synthesis of Bis-(asparaginato)palladium(II) (10)
Following the standard procedure, 0.0259 g palladium(II) acetate (1.15
×
10−4 mol)
and 0.0335 g asparagine (2.54
×
10−4 mol, 2.2 equivalents) were combined. The yield of
product was 39.7 mg (0.1077 mmol, 93% yield). Pd(C4H7N2O3)2 was identified based on
1
the following data: H NMR (400 MHz, Deuterium Oxide)
δ
3.93–3.79 (m, 1H), 2.88–2.63
(m, 2H). HRMS/ESI+ (m/z): [M + H]+ calcd for Pd(C4H7N2O3)2, 369.0021; found, 369.0050.
Anal. Calcd. for Pd(C4H7N2O3)2: C, 26.06%; H, 3.83%; N, 15.20%. Found: C, 26.20%; H,
3.72%; N, 15.28%.
4.1.11. Synthesis of Bis-(glutaminato)palladium(II) (11)
Following the standard procedure, 0.0218 g palladium(II) acetate (9.71
×
10−5 mol)
and 0.0312 g glutamine (2.14
×
10−4 mol, 2.2 equivalents) were combined. The yield of