Synthetic Communications p. 48 - 55 (2020)
Update date:2022-09-26
Topics:
Borase, Bhushan B.
Godbole, Himanshu M.
Singh, Girij P.
Upadhyay, Pritesh R.
Trivedi, Anurag
Bhat, Varadaraj
Shenoy, Gautham G.
A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.
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Doi:10.1016/j.tetlet.2020.152642
(2020)Doi:10.1016/S0008-6215(00)80680-1
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(2021)