Tetrahedron Letters p. 281 - 284 (1994)
Update date:2022-08-03
Topics:
Patterson, Kevin H.
Depree, Gary J.
Zender, Johannes A.
Morris, Peter J.
Methyl 4,5-diaminopentanoate (4,5-Dape Me) undergoes competitive intramolecular aminolysis to 5-aminomethyl-2-pyrrolidinone (L5) and 5-amino-2-piperidinone (L6) in dilute alkaline aqueous solution at 25°C. Use of this single compound provides an ideal case for assessing the relative rates of 5- and 6-membered lactam ring closure. Assessments are also made using the intramolecular aminolysis of pairs of compounds: methyl 2,4-diaminobutanoate (2,4-Dab Me) and methyl 2,5-diaminopentanoate (2,5-Dape Me); methyl 4-aminobutanoate (4-Ab Me) and methyl 5-aminopentanoate (5-Ape Me).
View MoreContact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
VanderArk International Limited
Contact:86-10-82437576
Address:Qing He
CGeneTech (Suzhou, China) Co., Ltd.
Contact:+86-512-62956962
Address:Room 101,Bld C11,218 Xinghu Rd.,Suzhou industrial Park
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Contact:86-28-61993785
Address:No.70-13-21, North Section, Erhuan
Doi:10.1021/jo049722p
(2004)Doi:10.1002/chem.201904132
(2019)Doi:10.1039/P19800000078
(1980)Doi:10.1002/hlca.19800630221
(1980)Doi:10.1002/ejoc.201700076
(2017)Doi:10.1016/j.bmc.2013.11.053
(2014)