Journal of Organic Chemistry p. 5994 - 5999 (1992)
Update date:2022-09-26
Topics:
Guram, Anil S.
Jordan, Richard F.
Sequential one-pot addition of alkylpyrazines, alkynes, and a proton source to a solution of Cp2Zr(Me)(THF)+ (1) in CH2Cl2 at room temperature affords (E)-alkenyl-substituted alkylpyrazines 2-10 in excellent yields.The regio- and stereoselectivity observed in these reactions is similar to those observed previously for related early transition metal-mediated reactions and is ascribed to steric and Si electronic effects.Conventional synthetic organic manipulation of the alkenylpyrazines provides easy access to a variety of highly substituted alkylpyrazines including tri- and tetrasubstituted alkylpyrazines 13, 17-20, dibromoalkylpyrazine 14, bromoalkylpyrazine 15, and epoxyalkylpyrazine 16.
View MoreTaizhou Crene Biotechnology co.ltd
Contact:86-576-88813233 88205808
Address:Economic Developed Zone of Taizhou Zhejiang China
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.
Contact:+86-750-2881198
Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
Xinchang Yueding Chemical Co., Ltd.
Contact:86-571-56926323
Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
JiYi Chemical (Beijing) Co., Ltd.
Contact:+86-10-89385733
Address:Shilou Town of Fangshan District, Beijing
Doi:10.1139/v66-226
(1966)Doi:10.1021/ja00221a093
(1988)Doi:10.1021/jm00226a016
(1976)Doi:10.1021/jo01279a027
(1967)Doi:10.1016/S0040-4039(00)77428-4
(1980)Doi:10.1080/00397911.2020.1771597
(2020)