Chemistry of Heterocyclic Compounds p. 704 - 707 (1980)
Update date:2022-08-04
Topics:
Gornostaev, L. M.
Zeibert, G. F.
Zolotareva, G. I.
The behavior of 3,5-dihalo derivatives of anthra<1,9-c,d>isoxazol-6-one with respect to primary and secondary amines was studied. 5-Chloroanthra<1,9-c,d>isoxazol-6-one undergoes amination particularly readily.The products of the reaction of isoxazoles with amines are the corresponding amino derivatives.The amination of 5-chloroanthra<1,9-c,d>isoxazol-6-one in refluxing dimethylformamide (DMF) is accompanied by reductive cleavage of the isoxazole ring and the formation of 1-amino-4-arylaminoanthraquinones.Amination in the 5 position with substitution of a hydride ion takes place primarily in the reaction of 3-chloroanthra<1,9-c,d>isoxazol-6-one with benzylamine or cyclohexylamine, whereas the chlorine in the 3 position is replaced by the action of morpholine or piperidine on the same substrate.
View MoreBeijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
Shanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
Contact:+86-18653358619
Address:zibo
Doi:10.1016/S0008-6215(00)85574-3
(1981)Doi:10.1021/acs.jmedchem.7b01295
(2017)Doi:10.1016/j.tet.2004.10.043
(2005)Doi:10.1021/ol048810t
(2004)Doi:10.1002/anie.201602695
(2016)Doi:10.1016/j.tetlet.2010.06.120
(2010)