Organic Process Research and Development p. 2157 - 2168 (2020)
Update date:2022-08-02
Topics:
Lebel, Hélène
Mathieu, Gary
Patel, Heena
The first continuous flow process was developed to synthesize N-methyl secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-methyl secondary amines were produced in good to excellent yields, including a number of bioactive compounds or their precursors. Up to 10.6 g (88% yield) of an N-methyl secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alcohol. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed.
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Doi:10.1016/S0040-4039(00)78697-7
(1980)Doi:10.1007/BF01168282
(1980)Doi:10.1007/BF00950586
(1980)Doi:10.1021/jm00135a012
(1981)Doi:10.1016/j.molcata.2014.05.017
(2014)Doi:10.1039/C19660000105
(1966)