Beilstein J. Org. Chem. 2017, 13, 120–126.
14.Blacker, A. J.; Breen, J. R.; Bourne, R. A.; Hone, C. A. The Growing
Impact of Continuous Flow Methods on the Twelve Principles of Green
Chemistry. Green and Sustainable Medicinal Chemistry; The Royal
Society of Chemistry, 2016; pp 140–155.
conversion was determined by 1H NMR. Afterwards, the sol-
vent was evaporated under reduced pressure to yield a yellow
semi-crystalline paste. Detailed reaction conditions and reagent
compositions for each experiment in the plate-type flow reactor
15.Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.
16.Myers, R. M.; Fitzpatrick, D. E.; Turner, R. M.; Ley, S. V.
17.Elvira, K. S.; Casadevall i Solvas, X.; Wootton, R. C. R.; deMello, A. J.
Supporting Information
Supporting Information File 1
18.Wiles, C.; Watts, P. Green Chem. 2012, 14, 38.
Analysis procedures, calculation of k-values, reactor
performance profiles, reactor fouling, emulsion stabilizing
properties, copies of 1H and 13C NMR and of GC-FID
spectra.
19.Watts, P.; Wiles, C. J. Chem. Res. 2012, 36, 181.
20.Ehrfeld, W.; Hessel, V.; Löwe, H. Microreactors: New Technology for
Modern Chemistry; Wiley-VCH Verlag GmbH: Weinheim, 2000.
21.Baxendale, I. R.; Hornung, C.; Ley, S. V.; de Mata Muñoz Molina, J.;
22.Micic, N.; Young, A.; Rosselgong, J.; Hornung, C. H. Processes 2014,
Acknowledgements
23.Hornung, C. H.; Guerrero-Sanchez, C.; Brasholz, M.; Saubern, S.;
Chiefari, J.; Moad, G.; Rizzardo, E.; Thang, S. H.
The authors thank Charlotte Wiles from Chemtrix BV for
helpful discussions and Matthew Waterford and Stuart Littler
for assistance with the operation of the Chemtrix Plantrix®
MR260 reactor.
24.Hornung, C. H.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V.
25.McMullen, J. P.; Jensen, K. F. Org. Process Res. Dev. 2011, 15, 398.
References
1. Romeo, L. M.; Catalina, D.; Lisbona, P.; Lara, Y.; Martínez, A.
2. Gallezot, P. Catal. Today 2007, 121, 76.
3. Behr, A.; Johnen, L. ChemSusChem 2009, 2, 1072.
License and Terms
4. Wilden, K.-G.; Alanko, P.; Uotila, M. Ann. Bot. Fenn. 1977, 14, 29.
5. Fekam Boyom, F.; Amvam Zollo, P. H.; Menut, C.; Lamaty, G.;
Bessière, J. M. Flavour Fragrance J. 1996, 11, 333.
This is an Open Access article under the terms of the
Creative Commons Attribution License
permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
6. Abaul, J.; Bourgeois, P.; Bessiere, J. M. Flavour Fragrance J. 1995, 10,
7. Bonaga, G.; Galletti, G. C. Anal. Chim. Acta 1985, 75, 131.
8. Shu, C.-K.; Lawrence, B. M. Reasons for the Variation in Composition
of Some Commercial Essential Oils. In Spices, Flavour Chemistry and
Antioxidant Properties; Risch, S. J.; Ho, C.-T., Eds.; American
Chemical Society Symposium Series, Vol. 660; American. Chemical
Society: Washington, 1997; pp 138–159.
The license is subject to the Beilstein Journal of Organic
Chemistry terms and conditions:
The definitive version of this article is the electronic one
which can be found at:
9. Orav, A.; Kailas, T.; Jegorova, A. Proc. Est. Acad. Sci., Chem. 2003,
52, 147–154.
10.Verma, M. K.; Anand, R.; Chisti, A. M.; Kitchlu, S.; Chandra, S.;
Shawl, A. S.; Khajuria, R. K. J. Essent. Oil-Bear. Plants 2010, 13, 331.
11.Goldblatt, L. A.; Palkin, S. Process for converting nopinene to myrcene.
U.S. Patent US2420131, May 6, 1947.
12.Dahill, R. J., Jr. Myrcene-methacrylonitrile adducts. U.S. Patent
US3714220, Jan 30, 1973.
13.Tabor, R.; Bernhardt, R. J.; Luxem, F. J.; Yao, C.; Wallace, G. J.
Surfactants and Solvents Containing Diels-Alder Adducts. WO Patent
WO2013148842, Oct 3, 2013.
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