38
GOOD ET AL.
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Leppert M, Leach RJ 1997 Genetic linkage of Paget’s disease
of the bone to chromosome 18q. Am J Hum Genet 61:1117–
1122.
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nant transformation in Paget’s disease of bone. Cancer 70:
2802–2808.
17. Nellissery MJ, Padalecki SS, Brkanac Z, Singer FR, Roodman
GD, Unni KK, Leach RJ, Hansen MF 1998 Evidence for a
novel osteosarcoma tumor-suppressor gene in the chromosome
18 region genetically linked with Paget’s disease of bone.
Am J Hum Genet 63:817–824.
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Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L
Anderson DM 2000 Mutations in TNFRSF11A, affecting the
signal peptide of RANK, cause familial expansile osteolysis.
Nat Genet 24:45–48.
ACKNOWLEDGMENTS
We are grateful to the family for their participation in the
research program. We gratefully acknowledge the assis-
tance of Dr. Robin J. Leach, Department of Cellular and
Structural Biology, University of Texas Health Science
Center, San Antonio, TX, USA, and Professor F.R. Singer,
John Wayne Cancer Institute at St. John’s Hospital and
Health Center, Santa Monica, CA, USA, who provided
DNA and clinical information for a pedigree member. This
study was supported by the Sylvia and Charles Viertel
Charitable Foundation, a National Health and Medical Re-
search Council of Australia Project Grant, and by the Prin-
cess Alexandra Hospital Research and Development Foun-
dation.
19. Haslam SI, Van Hul W, Morales-Piga A, Balemans W, San-
Millan JL, Nakatsuka K, Willems P, Haites NE, Ralston S
1998 Paget’s disease of bone: Evidence for a susceptibility
locus on chromosome 18q and for genetic heterogeneity.
J Bone Miner Res 13:911–917.
20. Miller SA, Dykes DD, Polesky HF 1988 A simple salting out
procedure for extracting DNA from human nucleated cells.
Nucleic Acids Res 16:1215.
21. O’Connell JR, Weeks DE 1995 The VITESSE algorithm for
rapid exact multilocus linkage analysis via genotype set recod-
ing and fuzzy inheritance. Nat Genet 11:402–408.
22. Rebel A, Bregeon C, Basle M, Malkani K, Patezour A, Filmon
R 1975 Osteoclastic inclusions in Paget’s disease of bone. Rev
Rhum Mal Osteoartic 42:637–641.
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Address reprint requests to:
Dr. Joanne Shaw
Department of Diabetes and Endocrinology
Princess Alexandra Hospital
Ipswich Road
Woolloongabba, Brisbane Q 4102, Australia
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Genet 3:359–361. 23, 2000; accepted August 24, 2000.