Journal of Medicinal Chemistry p. 1059 - 1063 (1981)
Update date:2022-08-02
Topics:
Tenthorey, Paul A.
Adams, H. Jack
Kronberg, George H.
Takman, Bertil H.
A series of 2,3-diaminopropionanilides was synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride and subsequent amination with the appropiate secondary amines.The target compounds were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity.Several of the active agents were found to have much higher antiarrhythmic potencies than lidocaine, but they were also toxic.Evaluation of the target compounds for local anesthetic activity in the formof sciatic nerve block in rats showed that most compounds had durations of block similar to that of lidocaine; none exhibited the long duration of block seen with etidocaine.
View MoreShandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Contact:+86-21-54391580
Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Doi:10.1002/ejoc.200600123
(2006)Doi:10.1021/jm100697g
(2010)Doi:10.1002/ejoc.201600051
(2016)Doi:10.1016/S0272-6386(05)80003-4
(1944)Doi:10.1021/jo00333a021
(1981)Doi:10.1021/ja00766a070
(1972)