Journal of Medicinal Chemistry p. 1353 - 1359 (1981)
Update date:2022-09-26
Topics:
Schaaf, Thomas K.
Bindra, Jasjit S.
Eggler, James F.
Plattner, Jacob J.
Nelson, A. James
et al.
In an effort to develop tissue-selective prostaglandin analogues resistant to the metabolic inactivating pathways of the natural materials, hybrid compounds modified both at C-1 with a sulfonimide moiety and in the n-amylcarbinol side chain with substituted phenoxy groups were synthesized and evaluated in a variety of in vitro and in vivo models.Several of these analogues exhibited potent, tissue-selective, uterine stimulant activity, a finding subsequently confirmed in clinical studies with one member of this series, N-(methanesulfonyl)-16-phenoxy-ω-tetranor-PGE2-carboxamide (CP-34089/ZK-57671, sulprostone).
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(2018)Doi:10.1006/bioo.2000.1175
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(1981)