N. Shahabadi, M. Mohammadpour / Spectrochimica Acta Part A 86 (2012) 191–195
195
4. Conclusion
In this paper, we studied the interaction of the NaMSA with
BSA via fluorescence, UV–vis and CD spectrum. The results of
fluorescence, UV–vis and CD spectra indicate that the secondary
structure of BSA molecules changes in the presence of NaMSA.
The experimental results also indicate that the quenching of flu-
orescence of BSA by NaMSA is a static quenching process. The
negative ꢀH and positive ꢀS values indicate that electrostatic
force and hydrogen bond played major roles in the NaMSA–BSA
binding reaction and contributed to the stability of the com-
plex.
This work provides some valuable information for the trans-
portation and distribution of NaMSA in vivo, and is helpful for
clarifying toxicity and dynamics of NaMSA.
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