S.Castang et al./ Bioorg.Med.Chem.Lett.14 (2004) 5145–5149
5149
for guiding us in its use. Financial support from the
´
Region Rhone-Alpes (Programme Emergence 2002),
the CNRS and the MENRT is gratefully acknowledged.
ˆ
References and notes
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Figure 6. Interaction of N-pentansulfonyl-L-homoserine lactone
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fonamides such as 1 and 8, may induce two distinct
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domains in a monomer (10A) and it can be supposed
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turbing this interface and the dimerisation process. On
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long (20A) but a cascade of structural rearrangements
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can be proposed. Such long distance mechanism is ob-
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of FixJ, a transcriptional activator protein of a related
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a carboxamide to sulfonamide substitution involves
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serine in TraR, a threonine, alter protein activation.26
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To conclude, a nonactive protein would be obtained in
the two cases, phenyl group at the end of the alkyl chain
in carboxamide analogues or sulfonamide moiety in sul-
fonamides analogues, explaining the observed absence
of synergic effect in compounds bearing the two struc-
tural modifications.
Acknowledgements
26. Chai, Y.; Winans, S. C. Mol.Microbiol. 2004, 51, 765–776.
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We thank Professor Loic Blum for generously making
his Luminometer available to us and to Agnes Degiuli