Journal of Organic Chemistry p. 2013 - 2018 (1982)
Update date:2022-08-03
Topics:
Jaroszewski, Jerzy W.
Oxidation of 3-ethoxy-4-hydroxy-, 4-hydroxy-3-methoxy-5-methyl-, 3-chloro-4-hydroxy-5-methoxy-, and 2-hydroxy-3-methoxybenzaldehyde with chlorous acid gives, by oxidative aromatic ring cleavage between the oxygen-bearing carbon atoms, derivatives of (2Z, 4Z)-2,4-hexadienedioic acid in low yields.Chlorous acid oxidation of 2-methoxyphenol and 3-hydroxy-4-methoxybenzaldehyde yields methoxy-1,4-benzoquinone and 5,5-dichloro-6,6-dihydroxy-2-methoxy-2-cyclohexene-1,4-dione, respectively.The hydrate as well as the corresponding methyl hemiacetal undergoes base-catalyzed ring contraction to a derivative of 1-hydroxy-4-oxo-2-cyclopentenecarboxylic acid.The kinetics of the ring contraction of the hydrate was investigated in aqueous solutions in the pH range 1.15-3.65, where the rearrangement appears to be subject to specific base catalysis.
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Doi:10.1002/ardp.19823150310
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