Journal of Organic Chemistry p. 2541 - 2549 (1982)
Update date:2022-08-05
Topics:
Ronald, Robert C.
Lansinger, Janet M.
Lillie, Thomas S.
Wheeler, Carl J.
The regioselective total syntheses of the novel fungal antibiotics frustulosin (1) and aurocitrin (2) were accomplished from 3,6-dihydroxy-2-iodobenzaldehyde (10) which was prepared by a regiodirected metalation of 2,5-dimethylbenzyl vinyl ether to establish the 1,2,3,4-tetrasubstitution pattern of these compounds.The unsaturated side chains of these hydroquinone antibiotics were attached by using the iodo aldehyde functionalities.The structures of these antibiotics are confirmed by synthesis.
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Doi:10.1021/ja01652a101
(1954)Doi:10.1016/S0008-6215(00)81033-2
(1982)Doi:10.1016/j.bmc.2004.09.002
(2004)Doi:10.1021/acs.joc.8b01358
(2018)Doi:10.1007/s11176-005-0416-6
(2005)Doi:10.1139/v82-081
(1982)
