Journal of Medicinal Chemistry p. 1077 - 1081 (1982)
Update date:2022-07-29
Topics:
Jardine, Ian
Strife, Robert J.
Kozlowski, John
The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused γ-lactone.This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2).To prevent this detoxification of the drug and to investigate whether the l
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Doi:10.1007/BF00503565
(1982)Doi:10.1002/jps.2600720807
(1983)Doi:10.1021/acs.joc.5b02098
(2016)Doi:10.1039/c5sc03590b
(2016)Doi:10.1021/ja806284x
(2008)Doi:10.1021/ol0478842
(2004)