Tetrahedron Letters p. 7823 - 7826 (2005)
Update date:2022-09-26
Topics:
Marcune, Benjamin F.
Hillier, Michael C.
Marcoux, Jean-Fran?ois
Humphrey, Guy R.
The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols 3. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives, 3a (X = Cl) was converted to 2-propyl-4-(4-chlorophenoxy)phenol 2a, a precursor to the PPARγ receptor agonist 1.
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