Canadian Journal of Chemistry p. 1996 - 2001 (1982)
Update date:2022-09-26
Topics:
Charlton, James L.
Sayeed, Vilayat A.
Lypka, Gerald N.
The anthracycline antibiotics daunorubicin and adriamycin are potent antitumor agents.It has recently been suggested that 5-oxaanthracycline analogs of these compounds might show reduced cardiotoxicity, a property that limits the clinical use of the anthracyclines.In this paper we describe the condensation-cyclization reactions of 2-methylchromone-3-carboxylate with cyclohexanones, a reaction that leads ultimately to the xanthocycline skeleton.
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