Journal of Organic Chemistry p. 5160 - 5167 (1982)
Update date:2022-08-05
Topics:
Floyd, David M.
Fritz, Alan W.
Pluscec, Josip
Weaver, Eugene R.
Cimarusti, Christopher M.
The cyclization of the O-methylhydroxamates 13-15 afforded excellent yields of the 1-methoxyazetidinones 16-18.Reductive cleavage of the methoxy group gave N-1-unsubstituted azetidinones 9, 19, and 20 which were sulfonated and deprotected, yielding zwitterions 29-31.These materials serve as general intermediates for the preparation of a large variety of monobactam antimicrobial agents.
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