Synthetic Communications p. 2041 - 2052 (2021)
Update date:2022-08-05
Topics: applications Scope and Limitations Transmetallation Reaction Conditions Oxidative Addition Reductive Elimination Pyridine (Py) N-Heterocyclic Carbene (NHC) Palladium (II) Advantages of NHC Ligands
Li, Dan
Tian, Qingqiang
Wang, Xuetong
Wang, Qiang
Wang, Yin
Liao, Siwei
Xu, Ping
Huang, Xin
Yuan, Jianyong
A mild, efficient, and practical catalytic system for the synthesis of highly privileged stilbene pharmacophores is reported. This system uses N-heterocyclic carbene palladium (II) Pyridine (NHC-Pd (II)-Py) complex to catalyze the formation of carbon-carbon bonds between olefin derivatives and various bromide. This simple, gentle and user-friendly method can offer a variety of stilbene products in excellent yields under solvent-free condition. And its scale-up reaction has excellent yield and this system can be applied to industrial fields. The utility of this method is highlighted by its universality and modular synthesis of a series of bioactive molecules or important medical intermediates.
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