Journal of the American Chemical Society p. 5002 - 5011 (1983)
Update date:2022-08-04
Topics:
Murahashi
Yoshimura
Tsumiyama
Kojima
It has been shown that primary and secondary amines undergo alkyl group exchange reactions upon treatment with palladium catalyst as depicted in an operationally simple and efficient reaction which provides a convenient method for synthesis of unsymmetrical amines. The application of the reaction for the preparation of various substituted amines and heterocyclic compounds such as hexahydropyrimidine tetrahydropyrimidine, imidazolidine, and imidazoles is described. The preparation of polyamines such as H//2N(CH//2)//mNH(CH//2)//nNH//2 (10) and H//2N(CH//2)//lNH(CH//2)//mNH(CH//2)//nNH//2 (l-n, equals 2,3; 11) is readily performed by the appadium-catalyzed reactions of azetidine (6) and aziridine (7) via azetine (9) and azirine intermediates. The mechanism the palladium-catalyzed reaction has been extensively studied on the carbonylation, racemization, and deuteurium-exchange reaction of (S)-( minus )- alpha -phenylethylamine (17).
View MoreXinjiang Zhongtai Chemical Co., Ltd.
Contact:+86-991-8788172
Address:NO.78 XISHAN RD.URUMQI,CHINA
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Jiangsu Feymer Technology Co., Ltd.
Contact:+86-512-58110622/58110118
Address:Fenghuang Town, Zhangjiagang City, Jiangsu Province, China
Contact:021-36356756
Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road, Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Doi:10.1021/ja01369a049
(1930)Doi:10.1039/jr9310000072
(1931)Doi:10.1021/jo01145a010
(1951)Doi:10.1021/jm049402y
(2005)Doi:10.1021/om50003a013
(1983)Doi:10.1002/hc.20112
(2005)