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RSC Advances
puried using column chromatography using hexanes/EtOAc in
an increasing polarity up to 1 : 1 mixture. The fractions con-
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lized in hexanes/EtOAc (1 : 1) to yield the desired product. All
compounds are fully characterized using 1H NMR, 13C NMR,
LC-MS and IR (see ESI† for detail).
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Conclusions
We have reported a convenient and mild methodology to readily
convert commercially available carboxylic acids, including
indole-carboxylic acids, aliphatic-carboxylic acids and alpha-
amino acids into corresponding benzimidazoles. Due to
increased interest of such synthons in drug discovery, our
approach provides access to structurally diverse benzimidazoles
in a one-pot operation. The methodology is high yielding, acid-
free and tolerates various common functional groups. As our
research group and several other groups are highly interested in
structurally unique benzimidazoles, our methodology is
a considerable addition to the eld of organic chemistry and
medicinal chemistry.
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Conflicts of interest
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The authors declare no conict of interest.
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Acknowledgements
The authors thank the College of Pharmacy and Health
Sciences, the Department of Pharmaceutical Sciences and the
Office of Grants and Sponsored Research at St. John's University
for their nancial support for research.
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