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ACS Chemical Biology
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2
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REFERENCES
5
6
7
8
1.
2.
3.
4.
Dawson, Mark A., and Kouzarides, T. (2012) Cancer Epigenetics: From Mechanism to
Therapy, Cell 150, 12ꢀ27.
Copeland, R. A. (2013) Molecular Pathways: Protein Methyltransferases in Cancer, Clin.
Cancer Res. 19, 6344ꢀ6350.
Chesi, M., and Bergsagel, P. L. (2011) Many Multiple Myelomas: Making More of the
Molecular Mayhem, ASH Education Program Book 2011, 344ꢀ353.
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
Chesi, M., Nardini, E., Lim, R. S. C., Smith, K. D., Kuehl, W. M., and Bergsagel, P. L.
(1998) The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene,
MMSET, Resulting in IgH/MMSET Hybrid Transcripts, Blood 92, 3025ꢀ34.
Keats, J. J., Reiman, T., Maxwell, C. A., Taylor, B. J., Larratt, L. M., Mant, M. J., Belch, A.
R., and Pilarski, L. M. (2003) In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic
factor irrespective of FGFR3 expression, Blood 101, 1520ꢀ9.
Rasmussen, T., Hudlebusch, H. R., Knudsen, L. M., and Johnsen, H. E. (2002) FGFR3
dysregulation in multiple myeloma: frequency and prognostic relevance, Br. J. Haematol.
117, 626ꢀ628.
Keats, J. J., Maxwell, C. A., Taylor, B. J., Hendzel, M. J., Chesi, M., Bergsagel, P. L., Larratt,
L. M., Mant, M. J., Reiman, T., Belch, A. R., and Pilarski, L. M. (2005) Overexpression of
transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)ꢀpositive
multiple myeloma patients, Blood 105, 4060–4069.
Mirabella, F., Wu, P., Wardell, C. P., Kaiser, M. F., Walker, B. A., Johnson, D. C., and
Morgan, G. J. (2013) MMSET is the key molecular target in t(4;14) myeloma, Blood Cancer
J. 3, e114.
5.
6.
7.
8.
9.
Garlisi, C. G., Uss, A. S., Xiao, H., Tian, F., Sheridan, K. E., Wang, L., Motasim Billah, M.,
Egan, R. W., Stranick, K. S., and Umland, S. P. (2001) A Unique mRNA Initiated within a
Middle Intron of WHSC1/MMSET Encodes a DNA Binding Protein That Suppresses Human
ILꢀ5 Transcription, Am. J. Respir. Cell Mol. Biol. 24, 90ꢀ98.
10.
MartinezꢀGarcia, E., Popovic, R., Min, D.ꢀJ., Sweet, S. M. M., Thomas, P. M., Zamdborg, L.,
Heffner, A., Will, C., Lamy, L., Staudt, L. M., Levens, D. L., Kelleher, N. L., and Licht, J. D.
(2011) The MMSET histone methyl transferase switches global histone methylation and alters
gene expression in t(4;14) multiple myeloma cells, Blood 117, 211ꢀ20.
Lauring, J., Abukhdeir, A. M., Konishi, H., Garay, J. P., Gustin, J. P., Wang, Q., Arceci, R. J.,
Matsui, W., and Park, B. H. (2008) The multiple myeloma–associated MMSET gene
contributes to cellular adhesion, clonogenic growth, and tumorigenicity, Blood 111, 856ꢀ64.
Brito, J. L. R., Walker, B., Jenner, M., Dickens, N. J., Brown, N. J. M., Ross, F. M.,
Avramidou, A., Irving, J. A. E., Gonzalez, D., Davies, F. E., and Morgan, G. J. (2009)
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14)
myeloma plasma cells, Haematologica 94, 78ꢀ86.
11.
12.
13.
Kuo, Alex J., Cheung, P., Chen, K., Zee, Barry M., Kioi, M., Lauring, J., Xi, Y., Park,
Ben H., Shi, X., Garcia, Benjamin A., Li, W., and Gozani, O. (2011) NSD2 Links
Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming, Mol. Cell 44, 609ꢀ
620.
14.
15.
Walker, B. A., Wardell, C. P., Chiecchio, L., Smith, E. M., Boyd, K. D., Neri, A., Davies, F.
E., Ross, F. M., and Morgan, G. J. (2011) Aberrant global methylation patterns affect the
molecular pathogenesis and prognosis of multiple myeloma, Blood 117, 553ꢀ62.
Jaffe, J. D., Wang, Y., Chan, H. M., Zhang, J., Huether, R., Kryukov, G. V., Bhang, H.ꢀe. C.,
Taylor, J. E., Hu, M., Englund, N. P., Yan, F., Wang, Z., Robert McDonald Iii, E., Wei, L.,
Ma, J., Easton, J., Yu, Z., deBeaumount, R., Gibaja, V., Venkatesan, K., Schlegel, R., Sellers,
W. R., Keen, N., Liu, J., Caponigro, G., Barretina, J., Cooke, V. G., Mullighan, C., Carr, S.
A., Downing, J. R., Garraway, L. A., and Stegmeier, F. (2013) Global chromatin profiling
reveals NSD2 mutations in pediatric acute lymphoblastic leukemia, Nat. Genet. 45, 1386ꢀ
1391.
16.
Oyer, J. A., Huang, X., Zheng, Y., Shim, J., Ezponda, T., Carpenter, Z., Allegretta, M., Okotꢀ
Kotber, C. I., Patel, J. P., Melnick, A., Levine, R. L., Ferrando, A., MacKerell, A. D.,
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