Journal of Organic Chemistry p. 51 - 56 (1984)
Update date:2022-08-04
Topics:
Takaku, Hiroshi
Kamaike, Kazuo
Tsuchiya, Hiromichi
The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine, cytidine, and N2-benzoylguanosine by treatment of 2',3'-O-(dibutylstannylene)uridine or NaH-treated nucleosides with 4-methoxybenzyl bromide.The 2'-O-(4-methoxybenzyl)nucleosides can be used as useful starting materials for the synthesis of 3',5'-linked ribooligonucleotides.The 4-methoxybenzyl group was removed rapidly from the ribooligonucleotides by treatment with triphenylmethyl fluoroborate, and the completely deblocked ribooligonucleotides were characterized by enzymatic hydrolysis.
View MoreJinhua Haoyuan Chemical CO., LTD
Contact:86-579-82465583
Address:Jinhua,Zhejiang
Beijing Merson Pharmaceutical Co., Ltd
Contact:0086-10-80484934 0086-10-80484574/
Address:2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road ,Shunyi District , Beijing 101318, P.R.China
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Xi'an caijing Opto-Electrical Science & Technology Co., LTD
Contact:+86-29-88294447
Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Zhejiang Allied Chemical Co.,Ltd
Contact:18967038207
Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Doi:10.1021/acs.orglett.1c01518
(2021)Doi:10.1002/anie.200502527
(2006)Doi:10.1016/S0040-4039(00)86032-3
(1983)Doi:10.1021/jo5011735
(2014)Doi:10.1039/c39830000849
(1983)Doi:10.1021/ja058692k
(2006)