HETEROCYCLES, Vol. 66, 2005
687
N-acryloyl-N-benzenesulfonyl-2-aminostyrene
as
a
white
solid.
To
a
solution
of
N-acryloyl-N-benzenesulfonyl-2-aminostyrene (90 mg, 0.27 mmol) in 27 mL of toluene under an Ar
atmosphere, was added catalyst C (8.6 mg, 0.014 mmol). The mixture was stirred at 80 oC for 5 h. After
removal of the solvent, the residue was purified by column chromatography on silica gel
(n-hexane:AcOEt = 3:1) followed by recrystallization from AcOEt to give 73 mg (90%) of 8b as colorless
crystals. mp 144 oC; 1H NMR (CDCl3) δ 8.47 (1H, d, J = 8.8 Hz), 8.12 (2H, d, J = 8.3 Hz), 7.65 (1H, dd,
13
J = 7.1, 7.8 Hz), 7.50-7.59 (5H, m), 7.33 (1H, dd, J = 7.3, 7.6 Hz), 6.38 (1H, d, J = 9.7 Hz); C NMR
(CDCl3) δ 161.9, 141.9, 139.7, 137.5, 134.1, 135.0, 128.9, 128.8, 128.7, 124.7, 122.2, 121.7, 119.2; IR
(KBr) 3451, 3060, 2921, 1666, 1591, 1448, 1363; LRMS (EI) m/z 285 [100].
ACKNOWLEDGEMENTS
This research was supported by Grants-in-Aid for the Encouragement of Young Scientists (A), for
Scientific Research (B), for Priority Area (A)(#17035014) and for Exploratory Research from the
Ministry of Education, Culture, Sports, Science and Technology, Japan. We also thank the Naito
Foundation and the Fujisawa Foundation for financial support.
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# Present address: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12, Nishi6,
Kita-ku, Sapporo 060-0812 JAPAN
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