Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

DOI: 10.1021/jm00369a024

Source and publish data:

Journal of Medicinal Chemistry p. 376 - 380 (1984)

Update date:2022-08-02

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Authors:

DeGraw DeGraw

Christie

Brown Brown

Kelly Kelly

Kisliuk Kisliuk

Gaumont Gaumont

Sirotnak

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Article abstract of DOI:10.1021/jm00369a024

The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox

Full text of DOI:10.1021/jm00369a024

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Article Doi

Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

DOI: 10.1021/jm00369a024

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00369a024

Full text of DOI:10.1021/jm00369a024

Products guided by the article

R&D Labs maybe for 88393-09-3

Relevant to this article

Photoinduced Electron Transfer in Polychromophoric Systems. 2. Protonation Directed Switching between Tri- and Bichromophoric Interaction.

Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles

Synthesis and characterization of gallium complexes bearing 4-alkyl-2,6-bis(aryliminomethylene)-phenol ligands; crystal structure of dimethyl[4-methyl-2,6-bis-(p-methylphenyliminomethylene)-phenolato]gallium

A metal-free approach to access ketones, amides, and nitriles employing TBAI/TBHP oxidative system in water

Synthesis and mass spectrometric analysis of cyclostellettamines H, I, K and L

Infrared spectra of new sulfur-nitrogen species in solid argon