Bulletin of the Chemical Society of Japan p. 3781 - 3785 (1983)
Update date:2022-08-05
Topics:
Ando
Takiguchi
Izumiya
Three cyclic tetradecapeptides related to gramicidin S (GS) were synthesized to investigate the contributions of the ring size of cyclic peptides and of the number of the basic amino acid residues to the antibacterial activity. The protected cyclic tetradecapeptides were synthesized through a cyclization reaction of the linear tetradecapeptide azide in pyridine. Hydrogenolysis of the protected cyclic peptides afforded crystalline tetrahydrochlorides of the analogs. The homogeneity of the analogs was ascertained by TLC, paper electrophoresis, and elemental analysis. In the experiment of circular dichroism, the two analogs with 7,7 prime -Pro or 7,7 prime -Sar gave spectra similar in shape to that of GS, while the analog with 7,7 prime -Gly gave a slightly different spectrum from that of GS.
View MoreShandong Dayi Chemical Co., Ltd.
website:http://www.dayi.com.cn
Contact:+86- 535-7388728. 15306386031
Address:No 1 Danya west road, Laiyang City, Shandong province
Weihao Chemtech (ChangZhou) Co., Ltd.
Contact:051989185693
Address:NO 217 huangshan Rd ,Changzhou
Taizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Zhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
Airsea(Taizhou) Pharmaceutical Limited
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Doi:10.1016/S0040-4020(01)97156-X
(1974)Doi:10.1021/ja00831a015
(1974)Doi:10.1016/S0040-4039(00)01972-9
(2001)Doi:10.1039/P19720002563
(1972)Doi:10.1515/znb-2001-0915
(2001)Doi:10.1021/ja01143a019
(1952)