Tetrahedron p. 3083 - 3090 (1983)
Update date:2022-08-05
Topics:
Crowe, D. F.
Christie, P. H.
DeGraw, J. I.
Fujiwara, A. N.
Grange, E.
et al.
A synthesis of dexamethasone multiply labeled with (13)C about the A ring is described. 16-α-Methyl-17α,20-dihydroxypregn-1,4,9(11)-trien-3,20-dione (1) was blocked as the bismethylenedioxy derivative and degraded to the ring C,D-fragment, Des-A,B-9-keto-16α-methyl-17α,20;20,21-bismethylenedioxypregn-8α-propionic acid (9).Conversion to the enol lactone and condensation with 1-diethylphosphono-4-pentanone-(13)C ethylene ketal followed by methylation and A-ring closure afforded the BMD derivative of 16α-methyl-pregn-4,9(11)-diene-3-one(13)C (14).The steroidal intermediate was further transformed to dexamethasone-(13)C.
View MoreContact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Contact:USA:563-513-3839
Address:No.121TANGU EAST STREET,SHIJIAZHAUNG,CHINA
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)
Contact:+86-512-69598882
Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
website:http://www.hanwayschem.com
Contact:+86-18502787239(whatsapp)
Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
Doi:10.1021/ja00319a022
(1984)Doi:10.1021/om050805l
(2006)Doi:10.1021/ja058112j
(2006)Doi:10.1021/ja0587796
(2006)Doi:10.1016/j.tetlet.2006.02.119
(2006)Doi:10.1021/ic011004n
(2002)
