Bioorganic and Medicinal Chemistry Letters p. 2661 - 2664 (2004)
Update date:2022-08-05
Topics:
Cheon, Hyae-Gyeong
Lee, Chul-Min
Kim, Beom-Tae
Hwang, Ki-Jun
N-Ureido-quinoxalinedione derivatives have been discovered as leads for a novel series of dipeptidyl peptidase-IV (DPP-IV) inhibitors through high-throughput screening of our chemical library. A brief structure-activity relationship of the compounds was investigated. Among them, entry 5 showed the most potent inhibitory activity. The nitro group in quinoxaline moiety and the aromatic sulfonyl substituted ureido functional group seem to be important to increase the potency dramatically.
View MoreContact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Hunan Zhongqi Pharmaceutical Co., Ltd
website:http://www.hnzqzy.com
Contact:0730-8722288 13807308622
Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Chengdu Baishixing Science and Technology Industry Co., Ltd.
website:http://www.cd-bsx.com
Contact:+86-28-88531548
Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Doi:10.1016/j.bmc.2017.11.036
(2018)Doi:10.1016/j.ica.2006.02.030
(2006)Doi:10.1039/c39830001147
(1983)Doi:10.1021/jo00183a024
(1984)Doi:10.1021/ol7022856
(2007)Doi:10.1002/cctc.202100051
(2021)