Journal of Pharmaceutical Sciences p. 87 - 90 (1984)
Update date:2022-08-04
Topics:
Shetty
Hawes
Midha
The propylpiperazine side chain of fluphenazine has been labeled with two, four, and six deuterium atoms by lithium aluminum deuteride reduction of the appropriate ester or imide. The γ-carbon of the propyl group was labeled with two deuterium atoms by reduction of 10- (2-methoxycarbonylethyl)-2-trifluoromethyl-10H-phenothiazine, while four deuterium atoms were incorporated into the piperazine ring by reduction of 10-[3-(3,5-dioxo-1-piperazinyl)propyl]-2-trifluoro-methyl-10H-phenothiazin e. The latter reduction gave the d4-labeled N-deshydroxyethyl metabolite of fluphenazine.
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