Journal of Organic Chemistry p. 2795 - 2799 (1984)
Update date:2022-08-05
Topics:
Olofson, R. A.
Abbott, Duain E.
Primary alkyl chlorides (R-Cl) are easily isolated in excellent yield after treatment of the appropriate N-alkylpiperidines (R-NC5H10) with α-chloroethyl chloroformate.The method is exemplified by the conversion of a variety of alkylpiperidines, including systems with other sensitive functionalities, to the respective chlorides in yields varying from 90 to 97percent.The potential significance of this process in drug congener preparation and in total synthesis is outlined.Similar fragmentations of N-sec-alkylpiperidines are described.
View MoreHangzhou Dawn Ray Pharmaceutical Co.,Ltd
website:http://www.dawnraypharma.com/
Contact:+86-571-85335020
Address:1018 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China
Tianjin Boron PharmaTech Co.,Ltd.
Contact:86-022-59845187
Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Contact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
website:http://www.konochem.com
Contact:86-29-86107037-8015
Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China
Doi:10.1248/cpb.10.372
(1962)Doi:10.1016/j.tetlet.2020.152016
(2020)Doi:10.1021/ja01872a029
(1939)Doi:10.1039/b605912k
(2006)Doi:10.1002/jps.2600550717
(1966)Doi:10.1016/S0040-4039(00)96047-7
(1987)