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Experimental Section
Typical Experimental Procedure
The (hetero)aryl bromide or iodide (5.0 mmol), nitrogen
heterocycle (7.5 mmol) [NB: for indole, azaindole and car-
bazole (6.0 mmol)], Cu2O (1–2 mol%), K3PO4 (10.0 mmol,
2.12 g) and ligand L4 (1–2 mol%) were placed into a Schlenk
tube (10 mL) with a magnetic stir bar. The reaction vessel
was evacuated and backfilled with argon three times, and
DMSO (1.5 mL) was added afterwards (NB: for liquid sub-
strates, they were added after the tube was backfilled with
argon). The reaction mixture was heated at 80–1208C for
24–36 h under vigorous stirring. The cooled reaction mixture
was partitioned between ethyl acetate and water. The organ-
ic layer was washed with water, brine, and dried over
Na2SO4, and concentrated under vacuum. The residue was
purified by column chromatography (eluting with ethyl ace-
tate/hexanes or dichloromethane/methanol) on silica gel to
afford the corresponding products.
Acknowledgements
The authors are grateful to the Chinese Academy of Sciences
(supported by the Strategic Priority Research Program),
(grant XDB20020200 & QYZDJ-SSW-SLH029) and the Na-
tional Natural Science Foundation of China (grant 21132008)
for their financial support.
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Adv. Synth. Catal. 0000, 000, 0 – 0
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