RSC Medicinal Chemistry
Research Article
14 X. He, S. K. Lakkaraju, M. Hanscom, Z. Zhao, J. Wu and B.
Stoica, et al. Acyl-2-aminobenzimidazoles: A novel class of
neuroprotective agents targeting mGluR5, Bioorg. Med.
Chem., 2015, 23(9), 2211–2220.
15 X. Guida, H. Jianhua and L. Xiaomin, Synthesis and QSAR
studies of novel 1-substituted-2-aminobenzimidazoles
derivatives, Eur. J. Med. Chem., 2006, 41(9), 1080–1083.
16 L. V. Lafrance, J. D. Leber, L. Mei and S. K. Verma,
Serotonin Transporter Affinity within
N-Aryloxyethylindolylalkylamines, J. Med. Chem., 2004, 47(15),
3823–3842.
a
Class of
24 A. Ramanathan and L. S. Jimenez, Reductive Dehalogenation
of Aryl Bromides and Chlorides and Their Use as Aryl
Blocking Groups, Synthesis, 2010, 2010(02), 217–220.
25 K. Garg, Y. Bansal, G. Bansal and R. K. Goel, Design,
synthesis, and PASS-assisted evaluation of novel
Benzimidazolecarboxamides
WO2010126922A1, 2010.
17 H. Takasugi, T. Terasawa, Y. Inoue, H. Nakamura, A.
Nagayoshi, H. Ohtake, Y. Furukawa, M. Mikami, K. Hinoue
and M. Ohtsubo, Preparation of pyridinyl-substituted
as
inhibitors
of
FAK,
2-substituted
benzimidazole
derivatives
as
potent
anthelmintics, Med. Chem. Res., 2014, 23(5), 2690–2697.
26 M. C. Jetter, M. J. Macielag, M. Xia and X. Xu, Benzimidazole
derivatives useful as transient receptor potential melastatin
subfamily type 8 channel modulators, WO2010144680A1,
2010.
benzamides
as
Apo
B
secretion
inhibitors,
WO2002028835A1, 2002.
27 G. Van Baelen, G. L. F. Lemière, R. A. Dommisse and
B. U. W. Maes, Synthesis of 5-methyl-5H-pyrroloij2,3-
c]quinoline and 4-methyl-4H-pyrroloij2,3-c]isoquinoline: two
new unnatural D-ring stripped isomers of the cryptolepine
series, ARKIVOC, 2009, 2009(6), 174–182.
28 S. B. Hoyt, C. London, D. Ok and W. H. Parsons, Preparation
of benzazepine amino acids as sodium channel blockers,
WO2007145922A2, 2007.
29 M. L. Sykes, J. B. Baell, M. Kaiser, E. Chatelain, S. R.
Moawad and D. Ganame, et al. Identification of
Compounds with Anti-Proliferative Activity against
Trypanosoma brucei brucei Strain 427 by a Whole Cell
Viability Based HTS Campaign, PLoS Neglected Trop. Dis.,
2012, 6(11), e1896.
30 S. Duffy, M. L. Sykes, A. J. Jones, T. B. Shelper, M.
Simpson and R. Lang, et al. Screening the Medicines for
Malaria Venture Pathogen Box across Multiple Pathogens
Reclassifies Starting Points for Open-Source Drug
Discovery, Antimicrob. Agents Chemother., 2017, 61(9),
e00379-17.
18 C. E. Brotherton-Pleiss, Z. Chen, S. D. Erickson, K. Kim, H.
Li, A. J. Lovey, Y. Qian, S.-S. So, P. M. Wovkulich and L. Yi,
Preparation of substituted carbamate compounds as
transient receptor potential (TRP) channel antagonists,
WO2014060341A1, 2014.
19 X. Geng and C. Wang, Rhenium-catalyzed C–H
aminocarbonylation of azobenzenes with isocyanates, Org.
Biomol. Chem., 2015, 13(28), 7619–7623.
20 C. Zanato, Approaches to the Total Synthesis of Dictyostatin
and Synthesis of epi-Dictyostatins, PhD thesis, Universita
Degli Studi di Milano, 2010.
21 J. R. Allen, J. J. Chen, M. J. Frohn, E. Hu, Q. Liu, A. J.
Pickrell, S. Rumfelt, R. M. Rzasa and W. Zhong, Preparation
of nitrogen heterocyclic compounds useful as 3′,5′-cyclic
nucleotide-specific phosphodiesterase 10 (PDE10) inhibitors,
WO2011143365A1, 2011.
22 P. Zhang, E. A. Terefenko, J. Bray, D. Deecher, A. Fensome
and J. Harrison, et al. 1- or 3-(3-Amino-2-hydroxy-1-phenyl
propyl)-1,3-dihydro-2H-benzimidazol-2-ones: Potent, Selective,
and Orally Efficacious Norepinephrine Reuptake Inhibitors,
J. Med. Chem., 2009, 52(18), 5703–5711.
23 R. E. Mewshaw, D. Zhou, P. Zhou, X. Shi, G. Hornby and T.
Spangler, et al. Studies toward the Discovery of the Next
Generation of Antidepressants. 3. Dual 5-HT1A and
31 M. P. Edwards and D. A. Price, Chapter 23 – Role of
Physicochemical Properties and Ligand Lipophilicity
Efficiency in Addressing Drug Safety Risks, In: Annual
Reports in Medicinal Chemistry, ed. J. E. Macor, Academic
Press, 2010, vol. 45, pp. 380–391.
This journal is © The Royal Society of Chemistry 2020
RSC Med. Chem.