Bioorganic and Medicinal Chemistry Letters p. 989 - 994 (2006)
Update date:2022-08-05
Topics:
Berlin, Michael
Ting, Pauline C.
Vaccaro, Wayne D.
Aslanian, Robert
McCormick, Kevin D.
Lee, Joe F.
Albanese, Margaret M.
Mutahi, Mwangi W.
Piwinski, John J.
Shih, Neng-Yang
Duguma, Luli
Solomon, Daniel M.
Zhou, Wei
Sher, Rosy
Favreau, Leonard
Bryant, Matthew
Korfmacher, Walter A.
Nardo, Cymbelene
West Jr., Robert E.
Anthes, John C.
Williams, Shirley M.
Wu, Ren-Long
Susan She
Rivelli, Maria A.
Corboz, Michel R.
Hey, John A.
A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.
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