Brief Articles
Journal of Medicinal Chemistry, 2007, Vol. 50, No. 6 1413
(14) Gualtieri, F.; Romanelli, M. N.; Teodori, E. The “frozen analog”
approach in medicinal chemistry. In Progress in Medicinal Chemistry;
Choundhary, M. I., Ed.; Harwood Academic Publishers: Amsterdam,
1996; Vol. 1 (Studies in Medicinal Chemistry), pp 271-318.
(15) Mondal, E.; Rani Sahu, P.; Bose, G.; Khan, A. T. A useful and
convenient synthetic protocol for interconversion of carbonyl com-
pounds to the corresponding 1,3-oxathiolanes and vice versa employ-
ing organic ammonium tribromide (OATB). Tetrahedron Lett. 2002,
43, 2843-2846.
(16) Karimi, B.; Seradj, H. Zirconium tetrachloride (ZrCl4) as an efficient
and chemoselective catalyst for conversion of carbonyl compounds
to 1,3-oxathiolanes. Synlett 2000, 6, 805-806.
(17) Altava, B.; Burguete, M. I.; Garc´ıa-Verdugo, E.; Luis, S. V.; Miravet,
J. F.; Vicent, M. J. On the origin of changes in topicity observed in
Diels-Alder reactions catalyzed by Ti-TADDOLates. Tetrahe-
dron: Asymmetry 2000, 11, 4885-4893.
(18) Scapecchi, S.; Marucci, G.; Angeli, P.; Bellucci, C.; Dei, S.; Gualtieri,
F.; Manetti, D.; Romanelli, M. N.; Teodori, E. Structure-activity
relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: Unex-
pected agonistic activity in a series of muscarinic antagonists. Bioorg.
Med. Chem. 2001, 9, 1165-1174.
(19) Budriesi, R.; Cacciaguerra, S.; Di Toro, R.; Bolognesi, M. L.;
Chiarini, A.; Minarini, A.; Rosini, M.; Spampinato, S.; Tumiatti, V.;
Melchiorre, C. Analysis of the muscarinic receptor subtype mediating
inhibition of the neurogenic contractions in rabbit isolated vas
deferens by a series of polymethylene tetra-amines. Br. J. Pharmacol.
2001, 132, 1009-1016.
(20) Haddad, E. B.; Trifilieff, A.; Landry, Y.; Gies, J. P. Heterogeneity
of guinea-pig lung muscarinic receptors revealed by [3H]4-DAMP-
binding. Pulm. Pharmacol. 1993, 6, 119-27.
(21) Roffel, A. F.; Davids, J. H.; Elzinga, C. R. S.; Wolf, D.; Zaagsma
J.; Kilbinger, H. Characterization of the muscarinic receptor subtype-
(s) mediating contraction of the guinea-pig lung strip and inhibition
of acetylcholine release in the guinea-pig trachea with the selective
muscarinic receptor antagonist tripitramine. Br. J. Pharmacol. 1997,
122, 133-141.
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