Monatshefte fur Chemie p. 581 - 586 (1984)
Update date:2022-07-29
Topics:
Afsah, E. M.
Hammouda, M.
Abou-Elzahab, M. M.
Double Mannich reaction of the title compound 1 with morpholine acetate in ethanol gave the symmetrical bis-base 2, whereas such reaction in acetic acid afforded the vinyl-ketonic base 3.Reactions of 3 with morpholine, piperidine, thiophenol and dimethyl phosphite were investigated.Mannich reaction of 2 with primary amines gave di-basically substituted γ-piperidones 6a-b.Compound 1 reacts with ethylenediamine and formaldehyde to give the diazatricyclic system 7. - Keywords: Symmetrical bis-Mannich bases; Bis(morpholinomethyl-γ-piperidones; 3,6-Diazatricyclo<4.3.1.1 3,8>undecanone; Nitrogen heterocycles
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