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Journal of Materials Chemistry B
Page 6 of 13
ARTICLE
Journal Name
PA(D/E)/siRNA was attributed the higher cell uptake, which
indicated higher cell uptake may not result in higher
cytotoxicity. Therefore, the homogenous core structure
together with suit pKa could enhance gene silencing efficiency
and biocompatibility at the same time. That is to say, the
dilemma between the higher gene silencing efficiency and
lower biocompatibility that has troubled polycationic micelles
as gene vectors could be resolved by the rational structure
design of the micellar core.
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Conflicts of interest
There are no conflicts to declare.
25 S. Guo, Y. Huang, W. Zhang, W. Wang, T. Wei, D. Lin, J. Xing, L.
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Acknowledgements
This work was supported by grants from the National Natural
Science Foundation of China (No. 31671021, 81502586, and
81773622).
26 Y. Huang, D. Lin, Q. Jiang, W. Zhang, S. Guo, P. Xiao, S. Zheng,
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