Organic Letters p. 2485 - 2488 (2002)
Update date:2022-08-05
Topics:
Langille, Neil F.
Dakin, Les A.
Panek, James S.
(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.
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