Organic Letters
Letter
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The current process could provide a practical method for the
synthesis of various biologically and chemically significant linear
carboxylic acids. Further development of the hydrocarboxyla-
tion reaction process is currently underway.
ASSOCIATED CONTENT
* Supporting Information
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S
The Supporting Information is available free of charge on the
Experimental procedures, characterization data, and
́
Chem. Commun. 2006, 2789−2791. (k) Tortosa Estorach, C.; Orejon,
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A.; Ruiz, N.; Masdeu-Bulto, A. M.; Laurenczy, G. Eur. J. Inorg. Chem.
2008, 2008, 3524−3531. (l) He, Z.; Hou, Z.; Zhang, Y.; Wang, T.;
Accession Codes
Dilixiati, Y.; Eli, W. Catal. Today 2015, 247, 147−154.
graphic data for this paper. These data can be obtained free of
bridge Crystallographic Data Centre, 12 Union Road, Cam-
bridge CB2 1EZ, UK; fax: +44 1223 336033.
(4) For leading references on metal-catalyzed hydrocarboxylation of
́
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AUTHOR INFORMATION
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Corresponding Author
ORCID
Author Contributions
§W.R. and J.C. contributed equally.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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(8) Sometimes the ratio of 2a to 3a could not be precisely determined
from the crude reaction mixtures by 1H NMR due to the overlap of acid
product signals with signals from other compounds such as solvents,
unreacted olefins, etc. The ratio was thus determined by 1H NMR of the
isolated product via alkalinization−washing−acidifying−extraction. In
principle, the ratio of 2a to 3a should remain the same during this
purification process.
We gratefully acknowledge the National Natural Science
Foundation of China (21632005, 21472083) and Changzhou
University for the financial support. We also thank Mr. Wei Liu
at Nanjing University for some experimental contributions.
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