100
G. Nirmala et al. / Spectrochimica Acta Part A 77 (2010) 92–100
nosa, K. pneumonia, B. cearus, and E. coli. The higher activity of the
complexes may be ascribed to Tweedy’s theory, according to which
chelation reduces the polarity of the central metal atom because of
partial sharing of its positive charge with the ligands, which favors
the permeation of the complexes through the liquid layer of the
ture of the compound, the solvent used, and the bacterial strain
under consideration. The antibacterial activity is also influenced
by the electron-inductive (+I or −I) nature of the substituents
[60,61]. The complexes containing electron-withdrawing group
shows higher activity than the complexes of ligand L1. The higher
antibacterial activity of metal complexes than the ligands is due
to an increase in cell permeability. The comparatively lower activ-
ity of certain complexes such as [NiL3](ClO4)2 than the complex
without electron-withdrawing group may be because of the lower
lipophilicity. This may decrease the penetration of the complexes
through the lipid membrane, which could neither block nor inhibit
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